ALLOGENOUS BONE MARROW TRANSPLANTATION FOR BONE MARROW FAILURE SYNDROME ON MOUSE MODEL

Abstract

Bone marrow failure (BMF) is a disease characterized by a drastic decline in the marrow's functional ability to produce blood cells. Emmanuel C Base et al (2008), the ratio of BMF disease in China, Asia is higher than Europe and US about from 3 to 4 fold. In Vietnam, the dangerous of BMF is ranked third among blood diseases (Vietnam Ministry of Health). Animal models of bone marrow failure syndromes have not only helped to strengthen our understanding of the mechanisms causing bone marrow failure but also applied for pre-clinical experiments. The aims of this research are: creating mouse (Mus musculus var Albino) models for bone marrow failure syndrome induced by chemicals such as busulfan and cyclophosphamide; and evaluating the treatment capacity of allogenous bone marrow transplantation on mouse models of BMF syndrome. The results showed that the combination of the two chemicals, the death rate caused by BMF can reach to 67%. The bone marrow transplantation can improve the alive ratio of mouse, which have bone marrow failure syndromes, from 33% to 88%.