Abstract
Pancreas, islets and embryonic stem cell transplantation have been clinically or experimentally explored for the treatment of diabetes, which have their own advantages and disadvantages. Pancreatic primordia transplantation is a new attempt. Since the pancreatic primordium contains precursor cell clusters of β cells which has high differentiation potential. These β cells have the potential to produce a large amount of insulin. What′s more, pancreatic primordia still has the advantages of avascularity and low immunogenicity. Pancreatic primordia transplantation can control the blood glucose level of immunocompetent animals for a long time. Pig pancreatic primordia xenotransplantation in mesentery of primates can get over the species barrier without using any immunosuppressive agents and induce immune tolerance, which provides a new idea for the treatment of human diabetes. Key words: Pancreatic primordia; Avascularity; Rejection; Diabetes; Organogenesis; Allotransplantation; Xenotransplantation
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