Abstract
Allicin, an antioxidant from garlic, is known to regulate intestinal contractions, but its effect on intestinal ion transport is unclear. The aim of this study was to examine the role of allicin in the regulation of electrogenic ion transport in rat intestine by measuring the transmural potential difference (ΔPD). Allicin induced significant positive ΔPD, when administered to the serosal side of the colonic mucosal-submucosal preparation. Allicin-induced colonic ΔPD was largely diminished by incubation in the chloride-free solution, although the transient peak of ΔPD after application of allicin remained. This transient peak of ΔPD was significantly diminished in both the chloride- and the bicarbonate-free incubation solution. Induction of ΔPD by allicin was greatly diminished by AP-18, an inhibitor of the transient receptor potential (TRP) cation channel subfamily A member 1, TRPA1. Both alliin and S-allylcysteine, the analogues of allicin, had no effect on ΔPD and did not affect allicin-induced ΔPD in the colon. These results suggest that allicin mainly evokes the electrogenic chloride secretion and only partially increases the electrogenic bicarbonate secretion via TRPA1.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
