Abstract
Cholestasis causes hepatic accumulation of bile acids leading to liver injury, fibrosis and liver failure. Andrographolide, the major active compound isolated from Andrographis paniculata, which is an indigenous plant and has been extensively used for liver diseases in Southeast Asia. However, the hepatoprotective effect on cholestasis has not been investigated yet. We administered andrographolide to rats for 2 days prior to alpha‐naphthylisothiocyanate (ANIT) injection for 2 days. Andrographolide pretreatment reduced ANIT‐induced increases serum aminotransferases, bilirubin, alkaline phosphates and gamma‐glutamyl transpeptidase. Histology of andrographolide administered to ANIT‐injected rats revealed less severe liver inflammation and bile duct proliferation than that in ANIT‐injected rats. In addition, andrographolide decreased the expression of tumor necrosis factor and monocyte chemoattractant protein‐1 in the ANIT‐injected rats. The protein expression of NF‐kB was also suppressed by andrographolide in the ANIT‐treated group. These findings indicated that andrographolide ameliorates cholestatic liver damage. The potential therapeutic action of andrographolide seems to be related to the inhibition of NF‐kB signaling. (This work was supported by Science Achievement Scholarship of Thailand (to T.K.))
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