Alleviate side effect of post-anesthesia recovery in patients with esophageal surgery by infusing different doses of dexmedetomidine

Abstract

Objective To observe alleviation of side effect in post-anesthesia recovery patients with esophageal surgery by continuous infusion of different doses of dexmedetomidine (DEX).Methods A total of 60 patients with esophageal cancer surgery were randomly divided into three groups,20 patients in each group.Before induction of anesthesia,0.8 μg/kg of DEX were pumped into patients of group D,then 0.4 μg·kg-1·h-1 of DEX were continuously infused till the end of surgery in group D1.0.2 μg·kg-1·h-1 of DEX were continuously infused till the end of surgery in group D2.patients of group C were continuously infused saline as controls.Mean artery pressure(MAP) and heart rate(HR) were recorded once in the recovery room(T1),extubation time(T2) and five min after extubation(T3).The recovery time,agitation score and Ramsay score were recorded,the Urapidil injection 25 mg or the esmolol injection 20 mg were given while blood pressure was＞180 mm Hg/100 mm Hg(1 mm Hg=0.133 kPa) or HR was＞110 bpm.Results the recovery time of group D1(30.3±4.7) min was significantly higher than group D2 and group C(P＜0.05),group D2 and group C had no difference (P＞0.05).MAP and HR of group D1 and group D2 at extubation were significantly higher than the recovery room.MAP and HR in group C at T2 (117±12) mm Hg,(107±8) bpm and T3 (108±9) mm Hg,(118±11) bpm were significantly increased compared with the recovery room (P＜0.05).MAP and HR in group D1(88±8) mm Hg,(79±5) bpm and group D2(93±8) mm Hg,(81 ±6) bpm at T2 were significantly descreased compared with group C.the dosage of urapidil and esmolol in group C were significantly increased compared with group D.agitation score of group C (2.9±0.4) significantly higher than group D1 (1.2±0.8) and group D2(1.4±0.6) (P＜0.05).the sedation score of group C (1.1 ±0.5) significantly lower than group D1 (4.5±1.2) and group D2(4.0±0.7)(P＜0.05).Conclusions DEX was able to alleviate the side effect of patients in post-anesthesia recovery.0.2 μg·kg-1 ·h-1 of DEX will not affect the recovery time and can inhibit postoperative agitation,and reduce the adverse effects in the anesthesia recovery period. Key words: Dexmedetomidine; Esophageal surgery; General anesthesia recovery period; Side effect