Allergy to walnuts and hazelnuts in atopic dermatitis patients and analysis of sensitization to molecular components

Abstract

ABSTRACTAimTo evaluate the occurrence of food allergy to walnuts and hazelnuts in atopic dermatitis patients.MethodsThe examination of specific IgE to molecular components with Multiplex ISAC testing was performed. The diagnosis of food allergy was confirmed in patients suffering from food reactions to walnuts/hazelnuts together with positive results of specific IgE to molecular components.Results and conclusion: Altogether 100 atopic dermatitis patients were examined – 48 men, 52 women, the average age 40.9 years. Hazelnuts allergy was confirmed in 25% of patients; these patients are majorly allergic to PR 10 protein, minorly to storage proteins. Walnut allergy was confirmed in 14% of patients; these patients are majorly allergic to storage proteins and to non-specific lipid transfer proteins. Sensitization to Bet v 1 homologues and profilins was associated with mild symptoms; nsLTPs and seed storage proteins were related to severe reactions.