Abstract
Althought serious illnesses can be transmitted by mosquitoes, the most frequent manifestations are due to the contact with saliva of mosquitoes during the blood meal. Culex and Aedes are meeting in countries with moderate climates. Clinical signs vary according to the immunoallergical response, from simple pruritic wheals to immediate and/or delayed allergic reactions. Some reactions can provoke confusion with an infectious cellulitis and an inappropriate antibiotherapy. The natural history of insect bite reactions in an individual tends to progress through 5 stages until immunizing tolerance settles down. Skin prick testing or Serum specific IgE of whole body extracts are lacking sensibility and specificity. Actually, they must be reserved for the most invalidating or severe cases. The recombinant allergens of the saliva of mosquitoes should allow to improve diagnosis and to envisage immunotherapy.
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