Abstract
Objective: This study aimed to evaluate the effects of acaricidal bait use on the house dust mite (HDM) allergen concentration and occurrence of allergic rhinitis (AR) and asthma symptoms in children sensitized to HDMs.Study Design: Sixty-six children (3–12 years old) with AR and asthma sensitized to HDMs were randomly assigned to receive an acaricidal bait intervention for 8 weeks and a placebo intervention for 8 weeks separated by a 4-week washout period. The visual analog scale (VAS) score, rhinitis control assessment test (RCAT) score, rhinoconjunctivitis quality of life questionnaire (RQLQ) score, asthma control questionnaire-5 (ACQ-5) score and HDM allergen levels were monitored.Results: HDM allergen levels were significantly decreased after 8 weeks (Δder p2+f2 2.282 (3.516) μg/g vs. 0.147 (0.25) μg/g, P < 0.05) in the acaricidal bait group compared with the placebo group. The VAS, RCAT and RQLQ scores in the acaricidal bait group were also significantly improved (ΔVAS 7.5 (16) vs. 3 (18), P < 0.05; ΔRCAT−3 (5) vs. 0 (7), P < 0.05; ΔRQLQ 4.5 (8) vs. 1 (8), P < 0.05), but the ACQ-5 score did not improve (ΔACQ-5 0.2 (0.4) vs. 0 (0.65), P > 0.05).Conclusion: Acaricidal bait reduced HDM exposure and improved rhinitis symptoms. This trial is registered at www.chictr.org.cn.
Highlights
Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa that is primarily mediated by IgE after the body is exposed to allergens
This study aimed to evaluate the effects of acaricidal bait use on the house dust mite (HDM) allergen concentration and occurrence of allergic rhinitis (AR) and asthma symptoms in children sensitized to House dust mites (HDMs)
HDM allergen levels were significantly decreased after 8 weeks ( der p2+f2 2.282 (3.516) μg/g vs. 0.147 (0.25) μg/g, P < 0.05) in the acaricidal bait group compared with the placebo group
Summary
Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa that is primarily mediated by IgE after the body is exposed to allergens. AR is characterized by typical nasal itching, sneezing, watery secretions, and nasal mucosal congestion [1]. Allergic asthma and AR are diseases that occur in different locations in the same airway, have similar pathological characteristics and exhibit chronic airway inflammatory responses. Epidemiological studies have shown that most asthma patients have rhinitis and that the presence of rhinitis is a risk factor for the development of asthma [2]. Some children with allergic asthma combined with rhinitis have poor asthma control because they neglect the triggers of rhinitis [3].
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