Allergic rhinitis as a key factor for the development of gastroesophageal reflux disease in children.

Abstract

Gastroesophageal reflux disease (GERD) may cause airway symptoms and some airway diseases exacerbate GERD symptoms. Asthma and allergic rhinitis (AR) have been identified as united airway disease because of their similar epidemiology and pathophysiology. Asthma has been considered a risk factor to develop GERD. However, the association between AR and GERD is not clear. We tried to investigate whether AR could increase the development of GERD. Children diagnosed as AR without a prior history of GERD were conducted from the National Health Insurance Research Database between 2000 and 2005. After propensity score matching, we enrolled 36,588 children with AR and 36,588 non-AR children as the controls. Cox regression models were adopted to calculate the hazard ratio (HR) of GERD. AR children had a significantly increased risk of GERD than non-AR children (adjusted HR 1.91, 95% CI=1.73-2.11, p<0.001), especially in the age less than 6 years old (adjusted HR 2.68, 95% CI=1.64-4.38, p<0.001). The risk factor related to increased risk of GERD including age, gender, and chronic sinusitis. AR is a risk factor associated with the development of GERD in children.