Allergic reactions to macrolide antibiotics in a 15-year-old population

Abstract

Macrolides are antibiotics that can be used to treat various infections. Allergic reactions to macrolides are rare, but may include minor to severe skin reactions, as well as systemic life-threatening reactions such as anaphylaxis. Hypersensitivity reactions can occur in any mode of administration and to almost all antibiotics. The purpose of the study was to determine whether there are reactions to macrolides in the study population, and to determine statistically significant differences in the occurrence of allergic reactions to macrolides between boys and girls of the same age and whether there are differences in the occurrence of allergic reactions between respondents in urban and rural areas. The sample consists of 1605 respondents, the sample was randomly selected and stratified by sex, and all data were processed in the statistical program. The results of the research show that 9.1% of the total population of boys and girls aged 15 from the Tuzla Canton are allergic to some type of antibiotic. The percentage of allergic reactions in the total population of 15-year-olds from suburban settlements is slightly higher than among peers in urban areas, but the differences are not statistically significant. A higher rate of allergic reactions was recorded in the group of boys from urban and rural areas. Macrolide allergies were found only in a group of boys in rural areas. This study confirmed that allergies to macrolides are rare and revealed differences in the occurrence of allergic reactions between girls and boys.