Abstract
Autoantibodies to small nuclear ribonucleoproteins (snRNPs) such as anti-Sm and U1RNP were among the first antinuclear protein responses identified in systemic autoimmune rheumatic diseases (SARD). Anti-Sm antibodies that recognize U1, U2, U5, and U4-6snRNPs are a marker for systemic lupus erythematosus (SLE) whereas anti-U1snRNP can be detected in various SARD, patients with overlapping features of certain SARD referred to as mixed connective tissue disease (MCTD), and unclassified patients with some features of rheumatic diseases.
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