Allergic inflammation

Abstract

Relatively not so long ago, the doctrine of the inflammatory response was enriched by the concept of "allergic inflammation" (von Pirquet 1907-08). However, the subsequent experimental and clinical study of these inflammatory forms has deepened our understanding of the pathogenesis of each inflammatory reaction so much that it can rightfully be called a stage in the new history of inflammation. From time immemorial, the doctor knew the variety of forms of development and course of inflammation. The construction of these numerous modifications of inflammation in most cases remained unclear. In his practice, each doctor encounters forms of extremely rapidly developing inflammation. Notae verae inflammationis is especially prominent in these cases. Tissue lesions end in necrosis. This one symptom already indicates the rapid development of this form of inflammation. But the rate of its formation can also be registered when studying other inflammatory signs preceding necrosis. A characteristic feature of the development of a normal skin test in an allergic person is the appearance within the first half an hour, literally "before the eyes" of the observer, hyperemia, edema on the periphery of the injection and even infiltration at the injection site.