Abstract
Histamine has been implicated in the pathogenesis of vasospastic angina, with coronary artery adventitial mast cells being a potential histamine source. Since histamine is a key mediator of allergic responses, the concept of allergic vasospastic angina (Kounis syndrome) has been introduced; however, histamine release may occur via both allergic and non-allergic pathways. Eosinophil-mediated allergic responses may induce vasospastic angina via histamine release.
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