ALLERGIC CONTACT DERMATITIS TO 2-OCTYL CYANOACRYLATE CONFIRMED BY PATCH TESTING: A PEDIATRIC CASE SERIES

Abstract

<h3>Introduction</h3> 2-octyl cyanoacrylate is a tissue adhesive commonly used to close wounds. While there have been multiple case reports regarding allergic contact dermatitis (ACD) to 2-octyl cyanoacrylate in the adult population, there is little in the literature regarding ACD to 2-octyl cyanoacrylate in the pediatric population. <h3>Methods</h3> A retrospective chart review was completed to identify patients who underwent patch testing to 2-octyl cyanoacrylate at a pediatric tertiary care center within the past 5 years. <h3>Results</h3> A total of 5 pediatric patients met inclusion criteria. All patients had a history of atopy. Four patients used 2-octyl cyanoacrylate previously without documented adverse reaction. Two patients had open patch testing and 3 had traditional occlusive patch testing. All patients were tested to multiple substances, and 3 of the 5 patients had reactions to other allergens in addition to 2-octyl cyanoacrylate. Four of five patients had reactions consisting of either erythema, pruritus, or pain within 24 hours of 2-octyl cyanoacrylate placement. All patients had positive reactions at 48 hours and strong or extreme positive reactions on subsequent readings. One patient required oral steroids for relief and the other 4 were treated with topical steroids. <h3>Conclusion</h3> 2-octyl cyanoacrylate can be a cause of ACD in pediatric patients. While reactions concerning for ACD can occur with many surgical products, a thorough history and patch testing can aid in identifying specific causative agents.