Abstract
Nasal cytology is a diagnostic tool currently used in rhinology to study either allergic and vasomotor rhinological disorders or infectious and inflammatory rhinitis. Over the past few years nasal cytology has been rarely used in pediatrics, nevertheless its clinical and scientific applications seem to be very promising. The advantages of this technique are different: the ease of performance, the noninvasiveness allowing repetition and the low cost. We evaluated 100 children, from 2 to 15 years old, referred to our outpatient service for allergic children for suspected allergic rhinitis (AR). After skin prick test (SPT) or Radio Allergo Sorbent Test (RAST), 59/100 subjects were classified as affected by AR, while 8 children refused to be tested. According to ARIA guidelines, the 59 children with AR (4 - 15 years old) were divided in 56 with persistent AR and 3 with an intermittent form. Nine out of 59 children with AR had a significant number of neutrophils and eosinophils at the nasal cytology, documenting the presence of “minimal persistent inflammation”. Eleven out of 59 AR patients showed a positive swab for bacteria. Children with nonallergic rhinitis (NAR) were 33/100 (2 - 15 years old). After nasal cytology, 17/33 children were classified as NARES (nonallergic rhinitis with eosinophils), including one X-linked agammaglobulinemia (XLA) child, 1/33 as NARESMA (nonallergic rhinitis with eosinophils and mast cell) and another 1/33 as NARMA (nonallergic rhinitis with mast cell). In conclusion, nasal cytology allowed us to correctly classify children with NAR and to better assess the condition of children with AR.
Highlights
Nasal cytology is a diagnostic tool currently used in rhinology to study either allergic and vasomotor rhinological disorders or infectious and inflammatory rhinitis [1,2,3].The rationale of this method is based on the knowledge that the nasal mucosa of healthy individuals is constituted by four cytotypes and does not show other cells except, rarely, neutrophils and, very rarely, bacteria
After skin prick test (SPT) or Radio Allergo Sorbent Test (RAST), 59/100 subjects were classified as affected by allergic rhinitis (AR), while 8 children refused to be tested
We had one child affected by X-linked agammaglobulinemia (XLA), whose SPT were negative and who suffered of recurrent rhinitis
Summary
Nasal cytology is a diagnostic tool currently used in rhinology to study either allergic and vasomotor rhinological disorders or infectious and inflammatory rhinitis [1,2,3]. The rationale of this method is based on the knowledge that the nasal mucosa of healthy individuals is constituted by four cytotypes (ciliata, mucipara, striata and basalis) and does not show other cells except, rarely, neutrophils and, very rarely, bacteria. The detection of eosinophils, mast cells, bacteria and fungal hyphae is a sign of a possible pathology [4]. In particular it provided an important contribution to the definition and understanding of the pathophysiologic mechanism of allergic and nonallergic rhinitis and to the identification of new pathological entities [9], such as the nonallergic rhinitis (NAR) with eosinophilia (nonallergic rhinitis with eosinophils, NARES), with mast cells (nonallergic rhinitis with mast cell, NARMA), neutrophilic forms (nonallergic rhinitis with neutrophils, NARNE) and, the eosinophil-mast cells (nonallergic rhinitis with eosinophils and mast cell, NARESMA) [10,11].
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
