Abstract
Subjects and methods Twenty adult PAR patients sensitive only to the mite D. farinae as diagnosed by Prick skin testing (PST) [Omega labs, Montreal, Canada] were included in the study. ASSIT to D. farinae was administered for 6 months. Flow cytometric evaluation of the intracellular expression of IL-4 and IFNgamma by CD3+ CD8+ T-cells was determined according to Manufacturer instructions (Beckton Dickenson) before and after ASSIT. The total 5 symptom score (T5SS) of PAR and the diameter of PST were also examined.
Highlights
Allergen specific sublingual immunotherapy (ASSIT) is a novel therapy of allergic diseases that gained significant acceptance over the past decade
This study was undertaken to investigate whether ASSIT in PAR may influence the Intracellular expression of IFN- gamma and IL-4 by CD3+CD8+ T-cells
ASSIT to D. farinae was administered for 6 months
Summary
Allergen specific sublingual immunotherapy (ASSIT) reduces Il-4 and enhances interferongamma intracellular expression by Cd8+ T-cells in perenneal allergic rhinitis (Par). Farag I Farag – Mahmod*, Wahid AM Ali, Waheed F Haysam, Sahar Z Zakaria, Gehan Elhadidy. From Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2012 Calgary, Canada. From Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2012 Calgary, Canada. 11-14 October 2012
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