Allergen Specific IgE Response Is Similar in HIV-1 Seropositive and Seronegative Adults: Implications for HAART Induced Th2 to Th1 Switching

Abstract

FEBRUARY 2015 AB8 Abstracts S A T U R D A Y 24 Allergen Specific IgE Response Is Similar in HIV-1 Seropositive and Seronegative Adults: Implications for HAART Induced Th2 to Th1 Switching Mili Shum, MD, Ashlei Mathew, MD, Maja Nowakowski, PhD, Hamid Moallem, MD, Tamar A. Smith-Norowitz, PhD, Helen G. Durkin, PhD, Rauno O. Joks, MD, FAAAAI; State University of New York Downstate Medical Center, Brooklyn, NY, Center for Allergy and Asthma Research, State University of New York Downstate Medical Center, Brooklyn, NY, Center for Allergy and Asthma Research at SUNY Downstate Medical Center, Brooklyn, NY, SUNY Downstate Medical Center, Brooklyn, NY, Center for Allergy and Asthma Research, SUNY Downstate, Brooklyn, NY. RATIONALE: Advanced HIV disease has been associated with Th2 mediated IgE responses, including IgE anti-HIV, and decreased atopy. The effect of HAART (highly active antiretroviral therapy) on Th2 mediated allergic IgE responses has not been determined. METHODS: Retrospective chart review was performed for adults seen in Allergy clinic at University Hospital of Brooklyn during 7/2000 to 5/2014. Subjects included HIV-1 patients on HAART and a control group consisting of HIV-1 seronegative patients (age and sex matched with a clinical visit in the samemonth). Total and allergen specific serum IgE was determined by ImmunoCAP assay; Skin prick test (SPT, Dermapik) for aeroallergens was performed using the Dermapik method. A mixed linear model was constructed for each dependent variable (IgE, no. of positive allergy results). Fixed factors were HIV status and gender; age was introduced as a linear covariate; matched pair ID was introduced as a random factor. RESULTS: Seventy-four subjects were analyzed with equal number of subjects in each group. HIV-1 seropositive subjects on HAART and controls had similar total serum IgE of 90.95 IU/ml and 144.54 IU/ml respectively (p50.23) and similar numbers of positive allergen specific IgE responses of 3.34 and 4.06, respectively (p50.28). CONCLUSIONS: These findings suggest there is limited effect of HAART on Th2 to Th1 switching.