Abstract
Objective The prevalence of frailty has been related to menopause. Our main objective was to investigate whether single nucleotide polymorphisms (SNPs) of the estrogen receptor (ER) ER α and ER β genes were related to the frailty phenotype in a population of community-dwelling postmenopausal women. Methods A cross-sectional study was performed in which we selected five SNPs, three in the ER α gene and two in the ER β . Linear regression was used to estimate the percentage of phenotypic variance after adjusting for confounding variables. Results A total of 470 women (mean ± standard deviation age 63.83 ± 8.16 years) were included, of whom 137 women were frail. The SNP rs3798577 of the ER α gene was the only variant associated with frailty, but this significance faded in the multivariant analysis. Body mass index (p = 0.012), number of comorbidities (0 vs. ≥2, p = 0.002) and two reproductive variables, number of miscarriages (none vs. ≥2, p = 0.036) and of childbirths (one vs. ≥3, p = 0.008), were independently related to frailty. Conclusion The five SNPs of the ER α and ER β genes tested were not correlated with frailty. Other SNPs of the ER warrant analysis to clarify whether variance in the gene response affects frailty status.
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Schedule a callMore From: Climacteric : the journal of the International Menopause Society
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