Allele Frequency of Apolipoprotein Gene Polymorphisms and Association between Genotype and Serum Lipid and Apolipoprotein Levels

Abstract

The rare allele frequency of the restriction fragment length polymorphism (RFLP) with Xba I (X+) at the apolipoprotein B (apo B) gene locus was 0.041 in men and 0.026 in women in H-Y district, Shiso County, Hyogo Prefecture, Japan : EcoR I at apo B gene (E-)=0.073 and 0.076, Msp I at apo Al-CIII gene (M-)=0.423 and 0.430, and Sac I at apo Al-CIII gene (S+)= 0.309 and 0.349. There was no marked ageor sex-difference in the frequencies. The frequencies of X+ and Ewere lower and those of S+ and Mwere higher in H-Y district than in Caucasian populations. In this population, according to the ANOVAs, the genotype for EcoR I was significantly (p<0.05) associated with serum total cholesterol, LDL cholesterol and apo B in women, and the genotype for Sac I with serum triglycerides and Msp I with serum apo CIII in men. The absolute values of Spearman correlation coefficients between genotypes and serum lipids or apolipoproteins were less than 0.2 after adjustment for age. J Epidemiol., 1995; 141-151.