Abstract
In this work, we explore the current knowledge about the phytochemistry and in vitro and in vivo evaluations of the extracts and, where appropriate, the main active components characterized and isolated from the Allamanda cathartica. Of the 15 Allamanda species, most phytochemical, pharmacological, and toxicological studies have focused on A. cathartica. These plants are used for the treatment of various health disorders. Numerous phytochemical investigations of plants from the A. cathartica have shown the presence of hydrocarbons, alcohols, esters, ethers, aldehydes, ketones, fatty acids, phospholipids, volatile compounds, phenolic compounds, flavonoids, alkaloids, steroids, terpenes, lactones, and carbohydrates. Various studies have confirmed that extracts and active substances isolated from the A. cathartica have multiple pharmacological activities. The species A. cathartica has emerged as a source of traditional medicine used for human health. Further studies on the phytochemical, pharmacological, and toxicological properties and their mechanisms of action, safety, and efficacy in the species of A. cathartica is recommended.
Highlights
The plant Allamanda is a very widespread group throughout the world
Through an in silico method, it was determined that some compounds present in A. cathartica have an antiviral activity against human hepatitis B viral capsid protein [58]
Extracts of 96% ethanol made from the leaves, branches, and stems of A. cathartica were evaluated for an in vitro haemorrhagic neutralization activity using the blood of a Swiss Webster mouse with 10 μg Bothrops atrox venom, and the results obtained showed a neutralization of 72 ± 8%
Summary
The plant Allamanda is a very widespread group throughout the world. Apocynaceae and, according to the “The Plant List,” contains approximately 15 species (A. augustifolia, A. blanchetti, A. caccicola, A. cathartica, A. doniana, A. laevis, A. martii, A nobilis, A. oenotherifolia, A. polyantha, A. puberula, A. schottii, A. setulosa, A. thevetifolia, and A. weberbaueri) [1]. The objective of this work is to present complete information about the current research on the distribution, phytochemistry, pharmacology, toxicity, and biotechnology of Allamanda cathartica; to identify its therapeutic potential; and to direct future research opportunities. The most relevant data were searched using the keyword “Allamanda cathartica” in “Google Scholar”, “PubMed”, “ScienceDirect”, “Scopus”, “Taylor & Francis”,. The taxonomy was validated using the “The Plant List”
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