Abstract
Recently, the main therapy of medullary thyroid cancer (MTC) is surgical, but by which way there is a poor prognosis with a mean survival of only 5 years. In some cases, some researchers found that it is the medullary thyroid cancer stem cells (MTCSCs) that cause metastasis and recurrence. This study aimed to eradicate MTCSCs through administration of all-trans-retinoic acid (ATRA). Here we demonstrate that MTCSCs possess stem- like properties in serum-free medium. The ABCG2, OCT4 and sodium iodide symporter (NIS) were changed by ATRA. Additionally, we found that ATRA can increase the expression of NIS in vivo. All the data suggested that ATRA could increase the iodine uptake of MTCSCs through NIS.
Highlights
medullary thyroid cancer (MTC) accounts around 5%-10% of thyroid cancer, and the death rate is more than 10%
Expression of OCT4, ABCG2 and NIS In order to prove the proteins of TT cells and TT
We assayed the expression of OCT4 and ABCG2 of TT cells and TT sphere cells (Figure 2A), In TT sphere cells, both of them had a higher expression levels than it in TT cells (Figure 2A)
Summary
MTC accounts around 5%-10% of thyroid cancer, and the death rate is more than 10% It has a poor capability of iodine uptake which limits the way of therapy. People believed that only a few cells of CSCs have the capacity to sustain the growth of tumor This subpopulation of cells are capable of self-renew, proliferate and differentiate into other tumor cells (Jiang et al, 2012; Tabarestani and Ghafouri-Fard, 2012; Francipane et al, 2013). It expresses high levels of ABCG2 and OCT4, which may cause their resistance to the conventional therapies of cancer (Tabarestani and Ghafouri-Fard, 2012; Zhang et al, 2012). If we find a way to eliminate the CSCs, we may cure the cancer
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