Abstract
AbstractA general strategy for the stereoselective total syntheses of cladospolides A, B, and C and iso‐cladospolide B has been accomplished. The key steps provide easy access to the target molecules and include an alkyne‐zipper reaction, a Sharpless asymmetric epoxidation/dihydroxylation, and a Yamaguchi macrolactonization. The feasibility of the alkyne‐mediated approach to construct the required carbon framework as well as to create the diol functionality and the olefin geometry is successfully demonstrated.
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