Abstract
Abstract Alkylation reaction of phosphates via tributylstannyl salt was applied to dinucleotide derivatives. Some alkyl groups were successfully introduced into the internucleotidic phosphate by use of alkyl bromides in the presence of tetraethylammonium bromide. In case of thymidylyl(3′-5′)thymidine, the phosphate moiety was alkylated selectively.
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