Abstract
Here, we present a versatile method for forming C(sp3)-C(sp3) bonds, enabling the synthesis of a range of natural and non-natural amino acids. This approach utilizes readily available glycine derivatives and alkyl iodides, combining single-electron transfer and halogen-atom transfer processes. The utility of this step-economic and redox-economic C(sp3)-C(sp3) bond formation is further highlighted in the late-stage site-selective modifications of the glycine residue in short peptides.
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