Abstract
Silver salts of various O-alkylhydroxamic acids react with 4-substituted 2-azetidinones (7) to produce novel substituted β-lactams. N- or O-alkylation of the hydroxamate silver salts can be controlled by reaction conditions, variation of the leaving group (OAc or SEt) of the 4-substituted 2-azetidinone, and the mode of formation of the silver salt itself. Elaboration of the products to azapenems and oxapenams may produce novel β-lactam derivatives for biological evaluation
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