Alkylation of γ-(4-nitrobenzyl)pyridine by four N-diazoacetyl derivatives of amino acids. Lack of fine correlation with the unscheduled DNA synthesis induced in mouse cells “In vitro”

Abstract

Summary Four N-diazoacetyl derivatives of amino acids, N-diazoacetylglycine amide (DGA), N-diazoacetylglycine methylamide (DGMA), N-diazoacetylglycine hydrazide (DGI), and N-diazoacetyl-D,L-alanine ethyl ester (DAE), two of them, DGA and DGI, known to be carcinogens and mutagens, were quantitatively assayed for both alkylation of the acceptor γ-(4-nitrobenzyl)pyridine and autoradiographic DNA repair induced in mouse cell cultures. All four compounds were positive for the above mentioned effects but there was no fine quantitative correlation between them.