Abstract
The phenotypic expression of intrinsic or natural resistance and the selection of acquired resistance through sublethal exposure to anticancer agents remain major obstacles to the successful treatment of human neoplasms. A large number of solid tumors that fail to respond to chemotherapy do so because they possess characteristics that allow them to circumvent pharmacological effects. Whether these characteristics are inherently present or are the result of acquisition through environmental selection (i.e., previous drug treatments, the common endpoint is expressed as failure to respond to therapy.
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