Abstract
The synthesis of four N-2-alkylated aza-galactofagomine (AGF) analogues was achieved by intermolecular reductive hydrazination or alkylation of suitably protected AGF. The synthesized compounds were evaluated as potential ?-glucosidase inhibitors. The preliminary screening of inhibitor activity, conducted with sweet almond ?-glucosidase immobilized in agar, as well as the standard inhibition assay with the same enzyme, showed inhibitory potency of the synthesized analogues. In addition, these results are in a good agreement with docking analysis of the human acid ?-glucosidase, the enzyme implicated in Gaucher's disease.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
