Abstract

Alkyl heteroaromatic as precursors to polycyclic heteroaromatics: Recent developments

Highlights

  • Alkyl groups linked to heteroaromatic π-deficient molecules are activated towards electrophiles both in acidic and basic media and in this way differ from alkyl aromatic hydrocarbons

  • Activity in basic media is attributed to ready formation of resonance stabilized carbanions

  • Activity in an acidic medium is attributed to the formation of methylene heteroaromatics as a result of protonation and deprotonation

Read more

Summary

Introduction

Alkyl groups linked to heteroaromatic π-deficient molecules are activated towards electrophiles both in acidic and basic media and in this way differ from alkyl aromatic hydrocarbons. Alkyl-substituted heteroaromatics have been utilized extensively as building blocks in heterocyclic synthesis and their utility in synthesis has been surveyed by one of us on 1997.6 Alkyl π-deficient molecules with electron-withdrawing substituents in adjacent positions are more useful as building blocks for synthesis of condensed heteroaromatics. Their utility for synthesis of condensed pyridines has been surveyed by Abou Shanab, Wakefield and Elnagdi.[6] Some time ago Elnagdi et al synthesised a variety of benzofused heteroaromatics and pyridofused heteroaromatics utilizing alkyl-substituted heteroaromatic carbonitriles as starting materials. 1,2,4-triazole 35 reacted with α-chloroketones 27 to yield compounds 36.25

Chemical Reactivity of Alkyl-substituted Heteroaromatics
Conclusions
Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.