Abstract
Hypervalent iodine reagents are of considerable relevance in organic chemistry as they can provide a complementary reaction strategy to the use of traditional transition metal chemistry. Over the past two decades, there have been an increasing number of applications including stoichiometric oxidation and catalytic asymmetric variations. This review outlines the main advances in the past 10 years in regard to alkene heterofunctionalization chemistry using achiral and chiral hypervalent iodine reagents and catalysts.
Highlights
Starting in the early 2000s, hypervalent iodine chemistry has undergone extensive development and a wide range of organic synthesis applications have been devised owing to their stability in air and to moisture, commercial availability, low toxicity, mild reaction conditions, and ease of handling
We provided an overview of the advances regarding hypervalent iodine-mediated
We provided an overview of the advances regarding hypervalent iodineand catalyzed alkene difunctionalization reactions in the past 10 years
Summary
Starting in the early 2000s, hypervalent iodine chemistry has undergone extensive development and a wide range of organic synthesis applications have been devised owing to their stability in air and to moisture, commercial availability, low toxicity, mild reaction conditions, and ease of handling. Most importantly, their complementary oxidizing ability compared to transition metals has been the main reason why they are increasingly being studied and used in synthetic organic chemistry.
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