Abstract
The relationship between alkanol chain length and effects on the transient potassium current, IA, were examined in three identified Aplysia californica neurons with ethanol (EtOH), butanol (BuOH), and hexanol (HxOH). Qualitative differences were found when the actions of EtOH were compared with those of the longer-chain-length alcohols. Whereas EtOH primarily affected the decay time constant of IA, having minimal effects on amplitude, BuOH and HxOH exerted their major effect on the amplitude of IA, reducing it, while their effects on decay kinetics were much less pronounced. The effects of EtOH on IA decay are cell specific among identified neurons of the Aplysia nervous system. The actions of BuOH and HxOH did not mimic these interneuronal differences. These data, coupled with data previously reported by us and others, make it unlikely that EtOH exerts its actions on IA via perturbation of a bulk lipid phase within the membrane.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.