Abstract

Five new alkylamides, undeca-2 E,4 Z-dien-8,10-diynoic acid isobutylamide, dodeca-2 E,4 Z-dien-8,10-diynoic acid isobutylamide, dodeca-2 E,4 E,10 E-trien-8-ynoic acid isobutylamide, dodeca-2 E,4 E,8 Z-trienoic acid isobutylamide and dodeca-2 E,4 Z-dien-8,10-diynoic acid 2-methylbutylamide were isolated from the roots of Echinacea purpurea. Undeca-2 E,4 Z-dien-8,10-diynoic acid 2-methylbutylamide is reported for the first time in an Echinacea species. The stereochemistry of the previously isolated major amides was determined as dodeca-2 E,4 E,8 Z,10 E-tetraenoic acid isobutylamide and dodeca-2 E,4 E,8 Z,10 Z-tetraenoic acid isobutylamide. All structures were elucidated by means of UV, IR, MS, 1H NMR and COSY NMR.

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