Abstract
The aim of the research was to study the aerial organs of Delphinium freynii conrath, common in Georgia, for the content of alkaloids and to determine their pharmacological activity. It was found that the sums of bases obtained by two methods are identical in terms of the qualitative composition of alkaloids and contain diterpene bases: methyllicaconitine, delfrenine, songoramine, anthranoillicoctonine, norzongoramine, norzongoine, delflexine, lycoctonine. In sum I (classical method), pharmacologically active methyllycaconitine dominates, and in sum II (extraction with 2% H2SO4) lyoctonine dominates. In “Hot plate” assay both samples reveal doze-dependent analgesic activity, reaching a maximum one hour after administration.
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