Abstract
Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodium-induced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.
Highlights
Aconitum carmichaelii Debx. (Ranunculaceae) is widely distributed and cultivated in China'sSichuan province [1]
The EtOH extract of the lateral roots of A. carmichaelii was suspended in water and successively partitioned with petroleum ether, EtOAc, and n-BuOH
The lateral root of A. carmichaelii was collected in July of 2010 from the culture field in Jiangyou, Sichuan postal code, China
Summary
Aconitum carmichaelii Debx. (Ranunculaceae) is widely distributed and cultivated in China's. (Ranunculaceae) is widely distributed and cultivated in China's. The parent and lateral roots of A. carmichaelii, two well known traditional. Chinese medicines, named “chuan wu” and “fu zi” respectively in Chinese, have been widely used in. Previous chemical studies of this plant have led to the isolation of more than 66 diterpenoid alkaloids, four flavonoids, a ceramide, a steroid saponin, and a pyrimidine [2,3,4,5]. In searching for bioactive natural products from “fu zi”, two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the lateral roots, together with five known compounds: fuziline (2) [8], neoline (3) [9], N-ethylhokbusine B (4) [10], 5-hydroxymethyl-pyrrole-2carbaldehyde (6) [11], and oleracein E (7) [12]. This paper describes the isolation, structure elucidation, and bioassays of these isolates
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