Abstract
From the seeds of Tabernaemontana cymosa ( = T. psychotrifolia) 17 indole alkaloids and six lignan glucosides were isolated, besides triacylglycerols, 9,12-octadecadienoic acid, lupeol, (+)-lyoniresinol, obtusifoliol, sweroside and a glucoside of 3- O-methylgallic acid. 9-(β- d-Glucopyranosyloxy)-tetrahydroalstonine, (+)-5,5′- dimethoxy-9-O- (β- d-glucopyranosyl)lariciresinol , (−)-2α-O- (β- d-glucopyranosyl)-lyoniresinol and 3-O-(β- d-glucopyranosyl )-5-O- methylgallic acid are described for the first time. Structural determination is based on spectroscopic studies and/or on comparison with authentic compounds. Some of the isolated substances exhibited significant antifungal and/or cytotoxic effects.
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