Abstract
Collagen extracted from tissues by alkaline treatment has a di erent isoelectric point (pI≈5) than the commonly-used acidor pepsin-treated collagen (pI≈9). In this study, the feasibility of using the alkali-treated collagen (AC) as a carrier of basic broblast growth factor (bFGF) for enhancement of angiogenesis was examined. AC hydrogels were prepared by chemically crosslinking AC molecules using glutaraldehyde (GA). We investigated the e ects of GA concentration in AC gels on the degree of swelling of the gels in an aqueous environment and on the in vivo degradation rate of the gels. Horse cytochrome c (pI: 9.6), a model for bFGF (pI: 9.6), electrostatically adsorbed to the AC gels. Subcutaneously-implanted AC gels incorporating bFGF led to enhanced angiogenesis compared with bFGF-free gels. Thus, AC gels incorporating bFGF appear to be useful materials for (i) the enhancement of angiogenesis and (ii) tissue engineering sca olds.
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