Abstract
Development of acute hepatitis in Swiss mice caused by a hepatotropic strain of ectromelia virus was investigated. Intraperitoneal application of a large dose of the virus resulted in death of all mice on the sixth day of acute hepatodystrophy. Agar gel electrophoresis was used to investigate the changes of isoenzymes of alkaline phosphatase, lactic dehydrogenase and aspartate aminotransferase in blood plasma and in liver homogenates during the infection. Remarkable changes of the activities of the two alkaline phosphatase isoenzymes were found in liver. Their activities change in the opposite direction already 48 h after the inoculation. The LDH 5 fraction of blood plasma started to increase 72 h after the inoculation. The LDH 1 and LDH 2 fractions of blood plasma were divided into subfractions. A second, more cathodic GOT isoenzyme was detected also in blood plasma beginning 96 hours after the inoculation. The characteristics of the changes under study are discussed.
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