Abstract
Tissue specimens exhibiting various stages of newly formed intramembranous bone with a fair amount of the osteoid matrix were obtained from the healing alveolar sockets of monkeys 1 and 2 weeks after tooth extraction. Comparison of adjacent sections demonstrating alkaline phosphatase activity and bone minerals, respectively, showed that, in the developing immature bone, extracellular enzyme activity was present not only in the osteoid matrix but also in the diffuse calcifying bone matrix.
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