Abstract
The aim of this study was to form a functional layer on the surface of titanium (Ti) implants to enhance their bioactivity. Layers of polyurethane (PU), containing hydroxyapatite (HAp) nanoparticles (NPs) and magnesium (Mg) particles, were deposited on alkali-treated Ti surfaces using a cost-effective dip-coating approach. The coatings were assessed in terms of morphology, chemical composition, adhesion strength, interfacial bonding, and thermal properties. Additionally, cell response to the variably coated Ti substrates was investigated using MC3T3-E1 osteoblast-like cells, including assessment of cell adhesion, cell proliferation, and osteogenic activity through an alkaline phosphatase (ALP) assay. The results showed that the incorporation of HAp NPs enhanced the interfacial bonding between the coating and the alkali-treated Ti surface. Furthermore, the presence of Mg and HAp particles enhanced the surface charge properties as well as cell attachment, proliferation, and differentiation. Our results suggest that the deposition of a bioactive composite layer containing Mg and HAp particles on Ti implants may have the potential to induce bone formation.
Highlights
Titanium (Ti) and its alloys are extensively used in orthopedic implants due to their favorable corrosion resistance, biocompatibility, machinability, and load bearing capability [1,2,3]
Surface chemistry plays an important role in the early stages of bone formation, with the greatest benefits derived from osteoconductive materials, such as hydroxyapatite HAp (Ca10 (PO4 )6 (OH)2 )
3 formed layer are the reason for the obtaining existed in the diffraction patterns small, and low intensity peaks were deimprovement in adhesion of the[46]
Summary
Titanium (Ti) and its alloys are extensively used in orthopedic implants due to their favorable corrosion resistance, biocompatibility, machinability, and load bearing capability [1,2,3]. Because of the bioinert nature of titanium, the osseointegration of Ti implants is relatively slow and can be compromised in sites of limited bone quality and quantity. Various methods of surface modification of Ti implants using physical, chemical, and biochemical treatment methods have been previously established [1,2,4,5], with the aim to enhance osseointegration of the Ti implants and promote their local bioactivity. HAp has been widely used for bone tissue engineering due to its excellent biocompatibility, bioactivity
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
