Abstract
Obesity and its associated metabolic disorders such as diabetes, hepatic steatosis and chronic heart diseases are affecting billions of individuals. However there is no satisfactory drug to treat such diseases. In this study, we found that alisol A, a major active triterpene isolated from the Chinese traditional medicine Rhizoma Alismatis, could significantly attenuate high‐fat‐diet‐induced obesity. Our biochemical detection demonstrated that alisol A remarkably decreased lipid levels, alleviated glucose metabolism disorders and insulin resistance in high‐fat‐diet‐induced obese mice. We also found that alisol A reduced hepatic steatosis and improved liver function in the obese mice model.In addition, protein expression investigation revealed that alisol A had an active effect on AMPK/ACC/SREBP‐1c pathway. As suggested by the molecular docking study, such bioactivity of alisol A may result from its selective binding to the catalytic region of AMPK.Therefore, we believe that Alisol A could serve as a promising agent for treatment of obesity and its related metabolic diseases.
Highlights
Obesity has undoubtedly become a global concern and affects more than 2.1 billion individuals worldwide.[1]
As we found that alisol A could activate the AMPK/acetyl‐CoA carboxylase (ACC)/SREBP‐1c pathway, we aim to find out its specific target
Obesity is associated with a high risk of some chronic diseases, including type 2 diabetes,[29] hy‐ perlipemia and non‐alcoholic fatty liver disease (NAFLD),[30,31] posing a significant threat to human health
Summary
Obesity has undoubtedly become a global concern and affects more than 2.1 billion individuals worldwide.[1]. Worrying is that several of these chemical drugs have unacceptable side effects[7] like steatorrhea, dry mouth, constipa‐ tion, headache and insomnia It is recommended these drugs only be prescribed when benefits of the treatment outweigh the risks. Rhizoma Alismatis, the dried rhizome of Alisma orientale, its effects mentioned in Chinese herbal medicine books are promoting urina‐ tion to drain dampness, discharging heat and resolving turbidity and lowering lipid.[15,16] With the deepening of modern medical research, it has been more widely studied. The AMP‐activated protein kinase (AMPKα)/acetyl‐CoA carboxylase (ACC) pathway seems to be involved in the anti‐obesity effects of alisol A
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