Abstract
Materials and methods Inspired by [3], we propose a new method that attempts to take advantage of multiple genomes and SNV information to align reads. This approach is promising in that it allows us to distinguish between sequencing errors and SNV. Our proposed alignment algorithm uses read fragments to identify seeds and extend these seeds to find occurrences of reads in the genome. In this study, we have developed and implemented an algorithm using multiple genomes that captures genomic variations, indexes the multiple genomes and operates short read alignment on a collection of genomes. The preliminary result was validated on Aspergillus fumigatus.
Highlights
Recent advances in biotechnology have enabled highthroughput sequencing of genomes based on large numbers of short reads
Materials and methods Inspired by [3], we propose a new method that attempts to take advantage of multiple genomes and single nucleotide variants (SNV) information to align reads
This approach is promising in that it allows us to distinguish between sequencing errors and SNV
Summary
Recent advances in biotechnology have enabled highthroughput sequencing of genomes based on large numbers of short reads.
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