Alice in Wonderland Syndrome and Lyme Disease

Abstract

In the 1865 novel, Alice in Wonderland , Alice proclaims it “curiouser and curiouser!” as she grows bigger and expands like a telescope after eating the cake she finds in a rabbit hole. Such distortions of form, size, and movement are characteristic of an abnormal sensory aura or perception termed “metamorphopsia” or “Alice in Wonderland syndrome.”1 Metamorphopsia can occur as a symptom of migraine or frontal lobe epilepsy.2,3 …