Abstract
Vaccination is used as a control and prevention tool for infectious bursal disease (IBDV) in poultry. A new strategy for improving vaccination efficiency is the use of in-feed immune modulating ingredients. The aim of this study was to test if the use of beta-(1,3)-glucans in feed can enhance IBDV vaccination. The trial was conducted in ROSS 308 broilers. In the study, a negative control group (not vaccinated, not supplemented), a positive control group (vaccinated, not supplemented) and a treated group (vaccinated, supplemented with beta-(1,3)-glucan) were included. All broilers, except the negative control, were orally vaccinated at 18 days of age with a live IBDV vaccine. Blood samples were taken at day 18 and 35 to measure antibody titers against IBDV. Serological analysis showed the presence of maternal derived antibodies at time of vaccination in some birds. The beta-(1,3)-glucan supplemented birds showed decreased CV% (coefficient of variation) and significantly increased average antibody titers compared to non-supplemented vaccinated birds. Additionally, the beta-(1,3)-glucan group showed increased number of birds with antibody titers above the titer threshold for protective immunity. The results obtained in the current trial clearly indicate that beta-(1,3)-glucan can increase seroconversion and serological response to IBDV vaccination.
Highlights
Vaccination plays a vital role in poultry health management
The beta-(1,3)-glucan supplemented birds showed decreased CV% and significantly increased average antibody titers compared to non-supplemented vaccinated birds
The results obtained in the current trial clearly indicate that beta-(1,3)-glucan can increase seroconversion and serological response to IBDV vaccination
Summary
Vaccination plays a vital role in poultry health management. Since the ban on the use of antibiotic growth promotors in animal production, there has been a growing interest in immunization and it is an important tool to reduce the use of therapeutic antibiotics. One of the most common viral infections in chickens, i.e. infectious bursal disease (IBDV), known as Gumboro disease, is caused by the IBDV virus. This virus destroys B-lymphocytes in the bursa of Fabricius and affects cell-mediated immunity, leading to mortality and immunosuppression resulting in poor performance with significant economic impact (Sharma et al, 2000; Müller et al, 2012; Ingrao et al, 2013). The vaccine is thought to be the cause, but a lot can go wrong between the moment of vaccine development and preparation, and the production of neutralizing antibodies by the animal (Marangon and Busani, 2007; Sharif and Ahmad, 2018). Monitoring antibody titers is important to guarantee efficient vaccination and to allow adjustment of vaccination programs, e.g. in case of protective IBDV maternal antibodies acquired through the egg yolk, the IBDV live vaccine is Ingredients (%)
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