Abstract
After reviewing the history of smallpox throughout the world and of the techniques used to try to prevent it (variolation and then Jenner's vaccine), we describe the epidemics that reached in the Indian Ocean between 1729 and 1859. Alexandre Reydellet, a Navy surgeon under Naoleon, arrived in Réunion in 1815 and stayed until his death in 1859. His energetic vaccination campaigns and their results are depicted.
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