Abstract
Reports of a possible relationship between Aleutian mink disease parvovirus (AMDV) and human infection are rare. However, 2 mink farmers with vascular disease and microangiopathy similar to that in mink with Aleutian disease were found to have AMDV-specific antibodies and AMDV DNA. These findings raise the suspicion that AMDV may play a role in human disease.
Highlights
Reports of a possible relationship between Aleutian mink disease parvovirus (AMDV) and human infection are rare
We report finding anti-AMDV antibodies and AMDV genome in tissue from 2 mink farmers with relevant virus exposure and clinical disease similar to that in mink with Aleutian disease (AD)
The clinical history, histopathologic features, and molecular findings for the 2 mink farmers exposed to AMDV were similar to those described for AD in mink
Summary
Reports of a possible relationship between Aleutian mink disease parvovirus (AMDV) and human infection are rare. AD is a persistent, slowly progressive AMDV infection in which a dysregulated immune system and a postinfectious antibody response cause an immune complex–mediated vasculitis [2]. Histopathologic features like those in AMDV-infected mink have been described for 2 patients in the early 1960s [10]. Into Aleutian mink caused neither lesions nor AMDV-antibody production [11].
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