Abstract
BackgroundTo identify high-risk patients and provide pharmacological treatment is one of the effective approaches in prevention of osteoporotic fractures. This study investigated the effect of 12-month Alendronate treatment on bone mineral density (BMD) and bone turnover biochemical markers in postmenopausal women with one or more non-traumatic fractures, i.e. patients with established osteoporosis.MethodsA total of 118 Hong Kong postmenopausal Chinese women aged 50 to 75 with low-energy fracture at distal radius (Colles' fracture) were recruited for BMD measurement at lumbar spine and non-dominant hip using Dual-Energy X-ray Absorptiometry (DXA). 47 women with BMD T-score below -2 SD at either side were identified as patients with established osteoporosis and then randomized into Alendronate group (n = 22) and placebo control group (n = 25) for BMD measurement at spine and hip using DXA and distal radius of the non-fracture side by peripheral quantitative computed tomography (pQCT), and bone turnover markers, including bone forming alkaline phosphatase (BALP) and bone resorbing urinary Deoxypyridinoline (DPD). All measurements were repeated at 6 and 12 months.ResultsAlendronate treatment significantly increased BMD, more in weight-bearing skeletons (5.1% at spine and 2.5% at hip) than in non-weight bearing skeleton (0.9% at distal radius) after 12 months treatment. Spine T-score was significant improved in Alendronate group (p < 0.01) (from -2.2 to -1.9) but not in control placebo group. The Alendronate treatment effect was explained by significant suppression of bone turnover.Conclusion12 months Alendronate treatment was effective to increase BMD at both axial and appendicular skeletons in postmenopausal women with established osteoporosis.
Highlights
To identify high-risk patients and provide pharmacological treatment is one of the effective approaches in prevention of osteoporotic fractures
In order to confirm our treatment effects, we identified patients with established osteoporosis for treatment and used bone mineral density (BMD) at both axial and appendicular skeletons as the end-point for evaluations
No difference is shown for the baseline BMD between Alendronate group and control group
Summary
To identify high-risk patients and provide pharmacological treatment is one of the effective approaches in prevention of osteoporotic fractures. This study investigated the effect of 12-month Alendronate treatment on bone mineral density (BMD) and bone turnover biochemical markers in postmenopausal women with one or more non-traumatic fractures, i.e. patients with established osteoporosis. Journal of Orthopaedic Surgery and Research 2007, 2:9 http://www.josr-online.com/content/2/1/9 oporotic fracture is to identify the high-risk patients and put them on effective pharmacological intervention programs. The aim of this study was to evaluate effects of 12-month Alendronate treatment in postmenopausal women with established osteoporosis. Bone mineral density (BMD) was used as the end-point and bone turnover biochemical markers were evaluated for monitoring bone metabolism in response to drug treatment effects
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