Abstract
The Aldosterone Secretion Rate (ASR) in patients with non-salt losing form of congenital adrenal hyperplasia (CAH) was studied. A Control group of nine subjects had an ASR (mean ± sd) of 94.0 ± 31.4 μg/d in basal conditions which, during salt deprivation, increased to 299.7 ± 103.6 μg/d. Ten patients during corticoid treatment had a value of 95.9 ± 45.8 μg/d; when therapy was discontinued for a period of 30–40 days it increased to 130.8 ± 29.2 μg/d and after sodium depletion to 336.3 ± 56.7 μg/d. However, five patients with CAH who had never been treated showed an ASR, significantly higher than the other groups (p < 0.01) either in basal condition, 349.1 ± 76.3 μg/d or during low salt diet 1099.1 ± 350.8 μg/d.
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