Abstract
Aldosterone is implicated in the pathogenesis of heart failure. Cardiac hypertrophy precedes heart failure and is its major risk factor. In this study, we examined whether aldosterone directly induces cardiac hypertrophy and, if so, whether sodium and Na+/H+ exchanger 1 (NHE1) are involved in this mechanism process.The sodium concentration in our culture mediums was altered within a physiological range from 141mEq/L to 146mEq/L. Cardiac hypertrophy was evaluated by measuring cell sizes, the level of incorporation of 3H-leucine and by the level of B-type natriuretic peptide (BNP) gene expression.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
