Aldo-Keto Reductases and Toxicant Metabolism

Abstract

SECTION 1: GENERAL OVERVIEW 1. Introduction and Overview of the Aldo-Keto Reductase (AKR) Superfamily SECTION 2: AKRS AND ENDOGENOUS TOXICANTS 2. Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes Associated With Diabetic Complications 3. Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates 4. Role of Aldose Reductase in the Detoxification of Oxidized Phospholipids SECTION 3: AKRS AND EXOGENOUS TOXICANTS: TOBACCO RELATED CARCINOGENS 5. Competing Roles of Reductases in the Detoxification of the Tobacco-Specific Nitrosamine Ketone NNK 6. Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons 7. Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from Mouse 8 Efficient Synthesis of the Active Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons 9. Chemistry of PAH o-Quinones Generated by the AKR Pathway of PAH Activation 10. Analysis of Etheno-2'-Deoxyguanosine Adducts as Dosimeters of AKR Mediated Oxidative Stress SECTION 4: AKRS AND EXOGENOUS TOXICANTS: MYCOTOXINS, ALDEHYDES AND KETONES 11. Aflatoxin Aldehyde Reductases 12. Competing Reactions of Aflatoxin B1-Dialdehyde: Enzymatic Reduction vs Adduction with Lysine 13. The use of mammalian cell lines to investigate the role of aldo-keto reductases in the detoxication of aldehydes and ketones SECTION 5: AKRS, THE STRESS RESPONSE AND CELL SIGNALING 14. Aldose Reductase and the Stress Response 15. Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory Signals 16. Aldo-Keto Reductases in the Stress Response of the Budding Yeast Saccharomyces cerevisiae