Abstract
Several studies indicate the mitochondrial Aldehyde Dehydrogenase‐2 (ALDH2) gene G487A polymorphism may be correlated with coronary artery disease (CAD) susceptibility, but a clear consensus has yet to be reached. To elucidate the relationship between the ALDH2 gene G487A polymorphism and CAD within the Chinese population, a meta‐analysis of 5644 subjects from nine individual studies was performed. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals were assessed using random or fixed‐effect models depending the heterogeneity existence or not. Our meta‐analysis found a significant association between ALDH2 gene G487A polymorphism and CAD in the Chinese population under allele (OR: 1.830, 95% CI: 1.560–2.140, P = 1.36 × 10−13), recessive (OR: 1.920, 95% CI: 1.530–2.390, P = 1.20 × 10−8), dominant (OR: 1.593, 95% CI: 1.336–1.900, P = 2.22 × 10−7), homozygous (OR: 2.280, 95% CI: 1.810–2.870, P = 3.17 × 10−12) and heterozygous genetic models (OR: 3.330, 95% CI: 2.070–5.370, P = 7.81 × 10−7). The positive correlation between the ALDH2 gene G487A polymorphism and CAD makes the mutation a strong candidate as a genetic risk marker for CAD. Through further analysis, we also found that A allele carriers of ALDH2 gene G487A polymorphism may be particularly susceptible to CAD.
Highlights
Coronary artery disease (CAD) is a disease that affects many middleaged and elderly people and is usually accompanied by hypertension, diabetes mellitus and dyslipidaemia
The studies were selected according to the following major criteria: (i) Evaluation of the relationship of CAD and aldehyde dehydrogenase-2 (ALDH2) gene G487A polymorphism. (ii) Coronary angiography was used to diagnose CAD with diagnosis criteria defined as the stenosis of one coronary artery by at least 50%. (iii) Studies were case–control or officially published cohort studies. (iv) The control group genotype followed Hardy–Weinberg equilibrium (HWE)
There was a significant association between ALDH2 gene G487A polymorphism and CAD in the Chinese population under allele (OR: 1.830, 95% confidence intervals (CIs): 1.560–2.140, P = 1.36 9 10À13), recessive (OR: 1.920, 95% CI: 1.530–2.390, P = 1.20 9 10À8), dominant (OR: 1.593, 95% CI: 1.336–1.900, P = 2.22 9 10À7), homozygous (OR: 2.280, 95% CI: 1.810–2.870, P = 3.17 9 10À12) and heterozygous genetic models (OR: 3.330, 95% CI:2.070–5.370, P = 7.81 9 10À7; Table 2; Figs 1–5)
Summary
Coronary artery disease (CAD) is a disease that affects many middleaged and elderly people and is usually accompanied by hypertension, diabetes mellitus and dyslipidaemia. To survey the current landscape of the research, we conducted a meta-analysis of 2887 CAD patients and 2757 controls from nine separate studies to evaluate the relationship of ALDH2 gene G487A polymorphism and CAD (Appendix S1).
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